John Carvalho, Ph.D.
- Biology
- California State University, Dominguez Hills
- jcarvalho@csudh.edu
I'm a member of
About me
I have a Postdoctoral Fellowship from Harvard Medical School, Boston, in Virology and a Ph.D. in Molecular Genetics from Washington University School of Medicine in St. Louis. My laboratory uses a variety of molecular genetic, cell biological, and biochemical technologies to study the orthoreoviridae, with an emphasis on understanding the structure-function of reovirus proteins, reovirus life cycle and reovirus-host cell interaction. In addition, we are studying the geographical/ecological expansion of the orthoreoviridae and other RNA viruses and their effects on equity healthcare in the developing world, especially for the most disadvantaged communities, with the aim of directing research that is biomedically relevant, lobbying for adequate research dollars for research agencies, and providing professional guidance and suggestions for international public policy that would maximize equity health and curb the threat of emerging infectious diseases.
Recent Publications (3 of 15 publications)
Carvalho, J. 2009. Our Common Enemy: Combatting the World’s Deadliest Viruses to Ensure Equity Healthcare in Developing Nations. Zygon 44: 141-154.
Carvalho, J. 2007. The Scientist as Statesman: Biologists and Third World Health. Zygon 42: 289-300.
Carvalho, J., M. Arnold and M. Nibert. 2007. Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2. Virology: 301-16.
Publications
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Carvalho, J. 2009. Our Common Enemy: Combatting the World’s Deadliest Viruses to Ensure Equity Healthcare in Developing Nations. Zygon 44: 141-154.
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Carvalho, J. 2007. The Scientist as Statesman: Biologists and Third World Health. Zygon 42: 289-300.
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Carvalho, J., M. Arnold and M. Nibert. 2007. Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2. Virology: 301-16.
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Carvalho, John, Michelle M Arnold and Max L Nibert. 2006. siRNA Silencing of Reovirus M1 mRNA/μ2 Protein Reveals Strain Differences in Associated Replication Defects and Complementation. Presented at American Society for Virology Conference, 2006, in Madison, WI.
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Carvalho, J. 2006. Overview of the Structure of a Scientific Worldview. Zygon 41: 113-124.
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Carvalho, John, Jonghwa Kim and Max L Nibert. 2004. Reovirus mu2 Protein Possesses Classical Nuclear Import/Export Signal Sequences and Shuttles Between Nucleus and Cytoplasm in Infected Cells. Presented at American Society for Virology Conference, 2004, in Montreal, Canada.
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Carvalho, J. 2004. Regulation of the GATA-Type Transcription Factor Gln3p by the Target of Rapamycin Protein (TOR). UMI Dissertation Publications.
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Carvalho, J. and X. Zheng. 2003. Domains of Gln3p interacting with karyopherins, Ure2p, and the target of rapamycin protein. The Journal of biological chemistry: 16878-86.
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Bertram, P.G., J. Choi, J. Carvalho, T. Chan, W. Ai and X.S. Zheng. 2002. Convergence of Snf1-Glucose and TOR-Nitrogen Signaling Pathways Onto Gln3p. Molecular and Cellular Biology 22: 1246-1252.
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Choi, J., P. Bertram, R. Drenan, J. Carvalho, H. Zhou and X. Zheng. 2002. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. EMBO reports: 988-94.
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Carvalho, J. and P.G. Bertram. 2001. On the Mechanism of Regulated Nucleocytoplasmic Transport of Gln3. Yeast 18: S176.
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Carvalho, J., P.G. Bertram, S.R. Wente and X.S. Zheng. 2001. Phosphorylation Regulates the Interaction Between Gln3p and the Nuclear Import Factor Srp1p. Journal of Biological Chemistry 278: 16878-16886.
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Chan, T., J. Carvalho, L. Riles and X.S. Zheng. 2000. A Chemical Genomics Approach Toward Understanding the Global Functions of the Target of Rapamycin Protein (TOR). Proceedings of the National Academy of Sciences, USA 97: 13227-13232.
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Bertram, P.G., J. Choi, J. Carvalho, W. Ai, C. Zeng and X.S. Zheng. 2000. Tripartite Regulation of Gln3p By TOR, Ure2p and Phosphatases. Journal of Biological Chemistry 275: 35727-35733.
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Carvalho, J. 1994. Genetic Analysis of the Ciguatera-Related Dinoflagellate Gambierdiscus toxicus. Fort Johnson research Review 6: 2-28.
Grants
Sally Casanova Memorial RSCAAP
Sally Casanova Memorial RSCAAP
United States National Research Service Award
NRSA Infectious Diseases and Basic Biological Mechanisms Training
Positions & Honors
2006 – XXV Annual ASV Postdoctoral Travel Award, American Society of Virology
2004 – XXIII Annual ASV Postdoctoral Travel Award, American Society of Virology
1995 – Summer Biological Research Fellowship, College of Charleston (Fellowship)
1994 – Award for Research Excellence in Biomedicine, Medical University of South Carolina
1994 – Summer medical Scientist and Research Training Program Award, Bayolor College of Medicine (Fellowship)
1992 – The John B. O'hara Chemical Sciences Award, John B. O'hara Chemical Sciences Program (Fellowship)
